This position will work in a lab that studies organ preservation, mitochondrial biology, and cardioprotection, providing a roadmap for next-generation preservation strategies, particularly in transplantation, advanced cardiovascular therapies, and translational science.
The candidate will investigate the role of Brd4-S in modulating chromatin configuration during cardiac preservation. He/She will further investigate how donor heart age, as an intrinsic biological factor, contributes to the primary graft dysfunction (PGD) after transplant.
The candidate will be responsible for the design and execution of experimental work, data analysis and their written records. Attendance and presence at internal, national and international meetings will be a key part of this role. Progress towards independent research is expected and papers published in in top scientific journals.
- Ph.D. and a minimum of 8 years' experience in basic and translational research
- A minimum of 15 publications in peer-reviewed journals and publications.
- Expertise in the roles of Brd4 and 3D chromatin architecture remodeling and aged donor heart preservation.
- Research interests in the following:
- metabolism-modulated Flot1 post-translational modifications affecting donor heart
preservation quality - deciphering the interaction of metabolic reprogramming and chromatin regulation during ischemia-reperfusion
injury in heart and liver - elucidating the epigenetic mechanism by which histone modifications regulate cardiac regeneration
and repair in heart failure.
University of Michigan Health System conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act.
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The University of Michigan is an equal employment opportunity employer.
