Role Description
Position Summary:
The Principal Scientist / Senior Principal Scientist is an experienced scientific leader within process chemistry, leveraging advanced knowledge across multiple disciplines to innovate, troubleshoot, and optimize complex chemical syntheses and scale-up processes. This role requires a highly motivated and independent leader with a proven track record in pharmaceutical or veterinary medicine research and development, capable of driving projects from lead candidate identification through commercial process technical transfer. The successful candidate will lead multi-disciplinary teams, applying deep technical and functional expertise to independently design and execute complex experiments and projects, often in ambiguous situations with significant uncertainty. As a key scientific resource, incumbent influences strategic direction, drives novel experimental approaches across multiple projects, and ensures alignment of work with departmental and organizational goals. The role demands strong people management skills, including mentoring, coaching, and career development of colleagues, while championing productivity improvements and fostering collaboration across functions. Additionally, the candidate may serve as a project leader for various corporate initiatives, providing strategic direction and driving alignment with broader organizational objectives in a global setting.
Essential Duties and Responsibilities:
Lead process chemistry efforts, including design, development, and scale-up of chemical syntheses for novel veterinary therapeutics.
Independently design, scale-up, and optimize synthetic processes from mg to multi-kilogram scale.
Apply the principles of green chemistry in API process design to select safer solvents and reagents, minimize waste, reduce environmental impact and improve overall efficiency.
Develop and execute impurity control strategies to ensure product quality, safety and regulatory compliance
Provide strategic direction and support across multiple projects simultaneously, acting as a scientific resource and technical leader within the group.
Lead technology transfer activities to commercial manufacturing facilities ensuring processes are safe, robust, economical, and environmentally responsible.
Collaborate effectively with cross-functional teams, understanding the significance and impact of decisions on project progression. Make recommendations to management regarding key sensitive and high impact decisions; involves stakeholders in important decisions affecting them.
Prepare and review technical and regulatory documentation, including CMC dossiers and development reports.
Develop and implement innovative strategies, tools, and technologies for continuous process improvement.
Collaborate with cross-functional teams to drive digital transformation initiatives in Process Chemistry.
Champion novel experimental approaches and business management tools to enhance productivity and impact.
Mentor and supervise colleagues, providing guidance, coaching, and career development support.
Represent the chemistry function on global research project teams and develop constructive relationships with internal and external partners.
Contribute to intellectual property strategy, including the protection and filing of small molecule IP.
Requirements:
Ph.D. in Synthetic Organic Chemistry with minimum of 8 years of industry experience in pharmaceutical or veterinary medicine, process chemistry research and development, and at least 2 years of leadership experience managing teams or projects.
Broad expertise in modern synthetic organic chemistry, with a track record of strategic and innovative solutions to synthetic problems. Proficiency in chemical literature searching (SciFinder, Reaxys, etc.), and in compound characterization and spectral analysis (HPLC, GC, NMR, UV, LC-MS).
Extensive hands-on experience in process chemistry scale-up, including multi-kilogram scale API manufacturing and technology transfer.
Experience with technical and... For full info follow application link.
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at [email protected] to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.
