A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The Fonseca Laboratory seeks a highly skilled Research Laboratory Specialist Lead to join an NIH-funded research program investigating how early-life respiratory viral infections alter lung development and drive long-term pulmonary disease. The position involves advanced molecular, cellular, and computational techniques using mouse and human systems.
The successful candidate will lead and support projects involving bulk and single-cell RNA sequencing (scRNA-seq), lung organoid development, confocal microscopy, in situ hybridization, and multi-omics analysis (ChIP-seq, ATAC-seq). The candidate will design and implement CRISPR/Cas9 genome-editing experiments, analyze complex datasets, and collaborate across multidisciplinary teams.
- Design and execute experiments involving bulk RNA-seq and scRNA-seq sample preparation, sequencing, and data analysis.
- Develop, culture, and analyze human and murine lung organoids; perform confocal imaging and in situ hybridization.
- Generate and analyze epigenetic datasets (ChIP-seq, ATAC-seq) and integrate multi-omics results.
- Design and perform CRISPR/Cas9 gene-editing and screening experiments.
- Manage data organization, documentation, and compliance with institutional standards.
- Contribute to manuscript preparation, grant reports, and supervision of trainees.
- Ph.D., in Molecular Biology, Bioinformatics, or a related field, with 6+ years of experience.
- Proven expertise with bulk and single-cell RNA sequencing workflows and data analysis.
- Hands-on experience developing and imaging 3D organoid cultures (human and/or murine).
- Demonstrated proficiency in epigenomic assays (ChIP, Chip-seq, or related).
- Experience designing and implementing CRISPR/Cas9 experiments.
- Excellent written, analytical, and organizational skills.
- Background in cell development, stem cell biology.
- Proficiency with bioinformatics tools (R, Python, Seurat, Cell Ranger, or similar).
- Experience with murine models and human samples processing.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal employment opportunity employer.
