Provide your CV with brief cover letter describing your research experiences and ongoing research interests (including specific interest in this lab) as well as contact information for three references.
Type 2 Diabetes (T2D) dysfunction and genetic associations involve mitochondrial biology pathways. The Parker lab seeks applicants to work on a project studying the effect of single-cell resolution and context-specific regulatory variants and transcriptional control elements at T2D GWAS signals. The focus will be on mitochondrial function in T2D disease-relevant cells/tissues. The individual will help organize and lead the research project involving molecular biology, statistical genetics, functional genomics, and metabolic assays using the Agilent Seahorse technology, and should serve as an expert in one of these specialized areas. The individual will also contribute to other research projects within the laboratory. The candidate should be able to work both independently and in a team environment and will be responsible for processing human tissue samples and cultured cell lines for these analyses. The candidate will be expected to perform basic laboratory maintenance/upkeep as well as maintaining compliance with University of Michigan safety and lab regulations. They will assist in development of research goals with responsibility for a substantial portion of project work and be expected to provide input into the development of procedures and research design.
Projects in the Parker lab are focused on human molecular genetic and metabolic techniques including cell culture, PCR, qPCR, gel electrophoresis, cloning, DNA and RNA isolation, library preparation for high-throughput sequencing, and Seahorse assays. These approaches are applied to human tissues and cells to profile molecular signatures at bulk and single cell multi-omics (RNA-seq, ATAC-seq) levels as well as to identify effects on mitochondrial and metabolic function. The candidate should be open to learning new cutting-edge methods and techniques as research opportunities develop and directions change.
B.S. in Cell Biology, Molecular Biology, or related field and 1-3 years of experience in a molecular biology lab setting with excellent cell culture, cell metabolism, and PCR/qPCR skills. The candidate should have strong written and oral communication skills and be able to critically evaluate and present scientific literature. The candidate will be asked to work collaboratively with senior research faculty and personnel, maintain laboratory records, and work under deadlines with general guidance. They will be expected to contribute to manuscripts, grants and presentations. English language proficiency is required.
M.S. degree or higher and more experience is preferred. Experience with the Agilent Seahorse technology is highly desired.
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