A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
Engineering research fellow position open to study brain metastasis using microfluidics.
The Merajver Laboratory in the Department of Internal Medicine, Division of Hematology/Oncology at the University of Michigan Medical School and Rogel Cancer Center is seeking an engineering postdoctoral fellow to join a translational research group investigating the brain tumor micro-environment?s role in promoting metastasis. Brain tumors are one of the most lethal complications of cancer and improved understanding may lead to improved outcomes for patients. Our interdisciplinary team has developed a blood brain barrier microfluidic platform (device, pump, sorting, imaging, analysis, AI) that is being used to study the process of brain metastasis from a diverse set of patient derived xenografts. Using this platform, we are looking to understand the biology of brain metastasis to develop diagnostics and therapeutics that reduce tumor burden. The first two years of the project you will be responsible for further developing the platform to extract multiplex single cell data. This would be accomplished by inclusion of an integrated pump to mimic brain flow and a novel approach for recovering live cells from the device.
Ph.D or MD degree
Useful skills include experience with some of the following: precision machine design, 3D printing (SLA, ?mSLA, polyjet), microfluidics (design and fabrication), MEMS (PDMS mold fabrication), microscopy (multiplex confocal), 3D image analysis and object tracking (VTK, OpenCV), optics, micro-pumps (piezo), python or MATLAB programming, artificial intelligence (neural networks and random forest). Experience with cancer biology a plus however other team members will provide biological knowledge and support to perform the experiments.
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