Position Summary
In immediate opening is available for a Research Associate (Post-Doctoral) in the Neubig Lab (Pharmacology & Toxicology, Michigan State University, East Lansing MI).
Seeking a candidate with strong experience in biochemistry, molecular pharmacology, and/or gene transcription mechanisms. Specific expertise in recombinant protein expression (especially mammalian or insect cells) as well as protein purification, biophysical analysis of protein structure/function, and small molecule binding analysis are desirable.
The ideal candidate will provide strong evidence of research productivity and drive. Recent PhD graduates preferred. The project relates to recently identified small molecule inhibitors of the Rho/MRTF/SRF gene transcription pathway (PMID: 23707258). They have been shown to have preclinical activity in fibrotic disease models and cancer metastasis (PMID: 24706986, 27837031). Based on the discovery of Pirin as a novel molecular target for these compounds (https://tinyurl.com/pirinpaper) and a role for pirin in the actions of multiple transcription factors including NF-kB, the candidate will undertake purification of pirin and characterize its interactions with and modulation of gene transcription. Interactions with and modulation by our small molecule inhibitors will also be explored.
Required Degree
Doctorate -Cancer Pharmacology or Cancer Biology
Minimum Requirements
Ph.D.
Desired Qualifications
- Ph.D. graduate
- Highly motivated scientist with experience in cancer pharmacology or cancer biology, and gene transcription analysis
- Provide strong evidence of research productivity and drive
Required Application Materials
Review of Applications Begins On
09/24/2019
Summary of Health Risks
Exposure to human blood, serum, tissue, and other body fluids; and materials covered under universal Michigan State University Environmental Health and Safety and MSU Occupational Health. Work with animals or unfixed animal tissue.
Website
HTTPS://PHMTOX.MSU.EDU/
MSU Statement
Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.
